Molecular and cellular biology of mycobacteria

The cell wall of mycobacteria contains mycobacteria-specific long-chain fatty acids, called mycolic acids, and mycolic acid-containing glycolipids. This highly hydrophobic structure of the cell wall of mycobacteria is critical not only for their acid-fast properties but also for their resistance to a variety of chemical attacks from the host cells, supporting their ability to survive for years within the host. On the other hand, the host T cells are capable of recognizing these critical lipid components of the cell wall of mycobacteria, such as glucose monomycolates, that are captured by group 1 CD1 molecules. These T cells are able to eliminate mycobacteria-infected cells. This opens the possibility for a new type of lipid-based vaccines against tuberculosis.