Clinical and Genetic Features of Children with Hutchinson-Gilford Progeria Syndrome: a Case Series and a Literature Review.

Hutchinson-Gilford progeria syndrome (HGPS, OMIM #176670) is an extremely rare genetic disorder caused by heterozygous mutations in LMNA gene, characterized by accelerated premature aging since childhood, causing multi-system alterations. 1 HGPS is still poorly recognized because of its rarity. To evaluate clinical manifestations and genetic features of HGPS children, we reported nine HGPS patients from department of Dermatology in Beijing Children's Hospital. The detailed information, including clinical characteristics, histopathology, and genetic feature, were summarized in Table 1.