Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.

Xing Feng,Heng Zhang,Lingbing Meng,Huiwen Song,Qingxin Zhou,Chao Qu,Pan Zhao,Qinghua Li,Chang Zou,Xing Liu,Zhiyong Zhang

Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.

2020

Xing Feng
Heng Zhang
Lingbing Meng
Huiwen Song
Qingxin Zhou
Chao Qu
Pan Zhao
Qinghua Li
Chang Zou
Xing Liu
Zhiyong Zhang

ABSTRACTAlthough the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, the precise mechanism underlying autophagy initiation and its signific...

Keywords:

Cell biology
Hypoxia (medical)
Ubiquitin
PAK1
ATG5
Acetylation
Biology
Phosphorylation
Autophagy
Carcinogenesis

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