claudin-3、4在食管鳞状细胞癌中的表达及其临床意义

Objective: To explore the expression of claudin-3, 4 in human esophageal squamous cell carcinoma and adjacent normal esophageal mucosa and its clinical significance. Methods: Immunohistochemistry SP method was used to detected the expressions of claudin-3, 4 protein and clinicopathological characteristics in fifty-four cases of esophageal squamous cell carcinoma and twenty-six cases of adjacent normal esophageal tissue. Results: The positive expression rate (92.6%) of claudin-3 protein in esophageal squamous cell carcinoma was significantly higher than adjacent normal esophageal mucosa (15.4%) (P＜0.01), the expression of claudin-3 protein was unrelated with sex, age, tumor size, histological grade, TNM stage, lymph node metastasis (P＞0.05), but was related with distant metastasis, the positive rate in distant metastasis were lower than those without distant metastasis (P＜0.05). The expression of claudin-4 protein was related with age and distant metastasis, the positive rate in distant metastasis and ≤60 years old were lower than those without distant metastasis (P＜0.05) and patients ＞60 years (P＜0.01). Conclusions: Claudin-3, 4 plays a catalytic role in esophageal squamous cell carcinoma pathogenesis, but when there is distant metastasis, the expression is low or lack.