Syntheses of new racemic NG‐(1‐iminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase

The efficient syntheses of three new racemic NG-(1-iminoethyl)phosphalysine derivatives are reported where the lysine carboxylate group is systematically replaced by phosphonic acid, 4, methyl phosphinic acid, 5, and phosphinic acid, 6. These compounds were evaluated as potential inhibitors of the three isoforms of human nitric oxide synthase. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:505–511, 2000