An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole
2010
Abstract This Letter outlines a new two-step process for the synthesis of 4-fluoropyrazole and its application in an improved synthesis of 4-fluoro-1-[5-fluoro-1-(1 H -imidazol-2-yl)-indan-4-ylmethyl]-1 H -pyrazole. The original synthesis of 4-fluoro-1-[5-fluoro-1-(1 H -imidazol-2-yl)-indan-4-ylmethyl]-1 H -pyrazole is also described.
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