Dulaglutide colon positioning sustained release preparation and preparation method thereof

The invention relates to the field of polypeptide drug positioning sustained release preparations, in particular to a dulaglutide colon positioning sustained release preparation and a preparation method thereof. The colon positioning sustained release preparation is composed of a tablet core or a core pellet, a sustained release layer, a pH control layer and a flora trigger layer. According to the dulaglutide colon positioning sustained release preparation, the objective of positioning sustained release of drugs can be achieved, the bioavailability of polypeptide is improved, and toxic and side effects are lowered. Compared with an injection, the dulaglutide colon positioning sustained release preparation particularly alleviates the irritation to the gastrointestinal tract, and a patient's compliance is improved.