Warm ischemic injury of orthotopic lung graft in dogs

In order to observe the influence of warm ischemia time(WIT)on canine cadaver donor lungs, 15 adult dogs were divided into three groups, group A with WIT for 1 h, group B with WIT for 2 h, and group C without WIT as control group.In the experiment, a model of mimicking left allograft lung transplantation was established and then PaO2, PaCO2, average pressure of the lung artery, wet/try weight ratio of ischemic lung, and type Ⅱ cell viability were recorded within 6 h to evaluate the function of the lung grafts.The results demonstrated that the cadaver donor lungs in group A had more severe reperfusion damage than in the control group, but the function of the lung grafts was still normal.The function of lung grafts in group B was poor and the damage to the lung tissue severe. Key words: Warm ischemia Dog lung Experimental study