The application and effect analysis of metronidazole controlled release pellicles and minocycline hydrochloride sustained-release agent on the treatment of chronic periodontitis

Objective To explore the effect of metronidazole controlled release pellicles and minocycline hydrochloride sustained-release agent on the treatment of chronic periodontitis.Methods 82 cases with chronic periodontitis were randomly divided into A group(metronidazole controlled release pellicles) and B group(minocycline hydrochloride sustained-release agent).The following indices were analyzed between both groups: general parameters(probing depth(PD),attachment level(AL),plaque index(PLI) and sulcus bleeding index(SBI)) and inflammatory cytokines in gingival crevicular fluid(interleukin-6(IL-6),interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α)) before treatment,and 1week,1 month and 3 months after treatment,as well as collagenase II activity(COL-Ⅱ) before treatment and 1 week,1 month and 3 months after treatment.Adverse reaction was also analyzed between two groups.Results The number of cases cured in group B was more than that in group A(P 0.05) 1 month after treatment,but the total effective rates were not different between two groups.Apart from PD 1 month after treatment,the general parameters,the inflammatory markers and COL-Ⅱ activity of gingival crevicular fluid of B group 1 and 3 months after treatment were better than those of A group(P 0.01,except IL-6,IL-8 one month after treatment and PD,AL(P 0.05)).There was no significant difference in adverse reaction between two groups(P 0.05).Conclusions The total effective rates of metronidazole controlled release pellicles and minocycline hydrochloride sustained-release agent on periodontitis were similar,but the long-term effect and inflammatory markers of gingival crevicular fluid and COL-Ⅱ activity of the latter were superior to the former.