Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique
1997
Abstract The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC 50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.
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