Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human

Abstract Background Sleeve gastrostomy (SG) induces significant weight loss primarily as a result of increased satiety and reduced food intake. Growth differentiation factor-15 (GDF15) is a satiety hormone which induces a dramatic reduction of food intake and body weight. Objective To assess the effect of sleeve gastrectomy on plasma GDF 15 level and the association with the weight loss and diabetes control after SG. Method We assessed plasma GDF15 level in 21 patients (15 with obesity and 6 with obesity and diabetes) before and then at 1, 3 and 12 months after SG. Results GDF15 was significantly increased at 1 month after SG compared to before surgery level (301.9 ± 135.2 pg/ml vs 215.1 ± 119.9 pg/ml, respectively p Conclusion SG induces a significant increase in GDF15 level which is correlated with the magnitude of BMI loss.