Discovery of potent CRTh2 (DP2) receptor antagonists.

Timothy Nicholas Birkinshaw,Simon J. Teague,Claire Beech,Roger Victor Bonnert,Stephen Hill,Anil Patel,Sara Reakes,Hitesh Sanganee,Iain G. Dougall,Timothy Phillips,Sylvia Salter,Jerzy Schmidt,Elizabeth C. Arrowsmith,Juan J. Carrillo,Fiona M. Bell,Stuart W. Paine,Richard Weaver

Discovery of potent CRTh2 (DP2) receptor antagonists.

2006

Timothy Nicholas Birkinshaw
Simon J. Teague
Claire Beech
Roger Victor Bonnert
Stephen Hill
Anil Patel
Sara Reakes
Hitesh Sanganee
Iain G. Dougall
Timothy Phillips
Sylvia Salter
Jerzy Schmidt
Elizabeth C. Arrowsmith
Juan J. Carrillo
Fiona M. Bell
Stuart W. Paine
Richard Weaver

Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP 2 ) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

Keywords:

Prostaglandin D2
Inflammation
Indometacin
Agonist
Allergy
Asthma
Biochemistry
Chemistry
Receptor
Antagonist
Immunology

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