Retromer and VSR Recycling: A Red Herring?

According to textbooks and most recent reviews, retromer is a trimeric protein complex that binds to the cytosolic tail of hydrolase receptors, e.g. vps10p in yeast, and the cation-independent mannosyl 6-phosphate receptor (CI-MPR) in mammals ([Gallon and Cullen, 2015][1]). Retrograde transport of