Levels and Significance of Adiponectin and Lipoproteins in Serum of Preeclampsia

Objective To explore the relationship between adiponectin (APN) and lipoproteins in the late pregnancy women with preeclampsia (PE). Methods From October 2008 to October 2010, a total of 40 cases of pregnancy women with PE were admitted in the Second Affiliated Hospital of Qingdao Medical University as PE group. According to severity grading of PE [severe preeclampsia (SPE) and mild preeclampsia(MPE)], they were divided into SPE group(n=22) and MPE group(n=18). Meanwhile another 40 healthy pregnancy women gestational ages as control group. The levels of serum APN, total triglyceride(TG), cholesterin(TC), low density lipoprotein(LDL)and high density lipoprotein (HDL) in 80 pregnant women at 34~38 weeks were measured with radioimmunoassay(RIA). There had no significant differences between PE group and control group, MPE group and SPE group among ages, gestational ages, parities(all first born), pregnant weight in late pregnancy, special past medical history and other pregnancy complications (P>0.05). This was a prospective observational study with institutional ethics approval and written subjects consent. Results ①The levels of serum APN and HDL were significantly lower in PE group than those in control group(P<0.01). The TG level was significantly higher in PE group than that in control group(P<0.01). ②The levels of APN and TG were negative correlated in PE group(r=-0.90, P<0.01). The levels of APN and HDL were positive correlated in PE group(r=0.93, P<0.01). Conclusions Lower APN and disturbance of lipid metabolism in late pregnancy might be associated with the pathogenesis of PE. Key words: preeclampsia; adiponectin; lipoprotein