Improved angiogenesis-inhibiting peptide and composition for preventing and treating angiogenesis-related disease comprising same as active ingredient

The present invention relates to improved peptides for inhibiting angiogenesis, Ac-RLYE and R (D) LYE, and a composition for the prevention and treatment of cancers and diseases related to angiogenesis comprising the peptides as an active ingredient. Specifically, the present invention relates to a peptide for inhibiting angiogenesis wherein the L-Arg of an N-terminal is acetylated in a peptide consisting of an amino acid sequence of Arg-Leu-Tyr-Glu, a peptide for inhibiting angiogenesis wherein L-Arg is substituted with DArg in a peptide consisting of the amino acid sequence of Arg-Leu-Tyr-Glu, and a method for using a composition comprising the peptides as active ingredients for the prevention or treatment of diseases (cancer, diabetic retinopathy or senile macular degeneration) caused by excessive angiogenesis. The peptides of the present invention have a long half-life and are excellent in VEGF-induced angiogenesis inhibitory effect. Therefore, the peptides developed in the present invention can be very effectively used for the prevention and treatment of diseases (cancer, diabetic retinopathy or senile macular degeneration) caused by excessive angiogenesis.