Target Delivery of Daunorubicin to Glioblastoma by Cyclic RGD-Linked PEG-PLA Micelles

Daunorubicin (Dau) has been widely used in the treatment of many solid tumors. However, the side effects of Dau seriously hinder its further application in clinical use. How to increase the drug accumulation in tumors and reduce the damage to normal tissues is an urgent problem to be solved. In this study, we developed c(RGDfK) decorated PEG-PLA micelles for target delivery of Dau to C6 glioblastoma cells. The enhanced uptake of cRGD decorated micelles by C6 cells were observed via CLSM and flow cytometry experiments. Moreover, the cRGD decorated micelles showed more cytotoxicity to C6 cells than undecorated micelles ex vivo. Therefore, cRGD decorated micelles represent a promising approach in improving drug accumulation for treatment of glioblastoma.