Comparison of liver steatosis quantification by MRS at 4.7 T and histology on ob/ob and db/db mice

Histology: Histological data showed an increase of steatosis for obese mice compared to wild-type mice. A significant difference (p<0.003) between wild-type and obese mice was obtained for the FF. This parameter gave high statistical difference (p<0.001) between wild-type and ob/ob mice. We also observed the increase of the FF with age for the ob/ob mice. MRS versus Histological data: Spearman test gave a high correlation (r=0.95, p<10 -6 MRS: The analysis of quantitative data obtained in MRS showed a significant increase in the FWR between the wild-type mice and the obese mice (p<0.003). This difference was particularly large between wild-type and ob/ob mice (p<0.001). An increase of the FWR versus age was also observed for the ob/ob mice. ppm