Prediction of Gestational Diabetes Mellitus by Soluble (Pro)Renin Receptor During the First Trimester

Context: There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RR] may contribute to the development of GDM. Objective: The objective of the study was to determine whether plasma s(P)RR concentrations during early pregnancy are associated with the development of GDM later in pregnancy. Design, Setting, and Participants: This prospective cohort study was conducted at a referral birth center. Pregnant women who first visited our hospital during the first trimester (<14 weeks of gestation) between 2010 and 2011 were enrolled. Inclusion criteria included singleton pregnancy and the absence of preexisting diabetes mellitus. A total of 716 women participated in this study. Main Outcome Measure: The association of plasma s(P)RR concentrations with the onset of GDM later in pregnancy was measured. Results: Among 716 participants, 44 (6.1%) had GDM and 672 (93.9%) did not. There were 176 participants in the fi...