Concentrations of α-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia

Abstract We determined the concentrations of α-tocopherol (α-TOH) and α-tocopherol quinone(α-TQ), an oxidized derivative of α-TOH, in cerebrospinal fluid from patients with Alzheimer type dementia (ATD) and those with vascular dementia of the Binswanger type (VDBT). Compared with results for the controls, the VDBT patients had unaltered concentrations of α-TOH, but a statistically significant, 3.6-fold increase of α-TQ ( P P P