Effect of EB virus on infectious mononucleosis in children effects of immune function

Objective To explore effect of immune function of children with EB virus infectious mononucleosis(IM). Methods From Sep. 2011 to Jun. 2013, a total of 62 cases of children with IM were analyzed retrospectively. The proportion of T-lymphocyte subsets,B-lymphocytesand and NK cells in EBV-DNA group with positive and negative were compared. Results The numbers of IM EBV-DNA-negative cases were 18(29.03%),the numbers of IM EBV-DNA-positive cases were 44(70.97%), the averages of EBV-DNA in positive group is 6.1× 103/ mL. CD3+,CD8+cell ratios in IM children are significantly higher than control group(P 0.01), CD4+,CD19+cell ratios are significantly lower than control group(P 0.01), NK cells are not significantly different(P0.05). In the IM children, CD4+, CD19+cells in DNA-positive group are significantly less than DNA-negative group(P 0.01), CD8+cells are higher than DNA-negative group(P 0.05), NK cells are not significantly different(P 0.05). Conclusions Positive blood EBV-DNA is closely related to changes in T-lymphocyte and Blymphocyte, but isn′t obviously related in NK cells. So effect of EB virus in IM child have certain clinical values to judge the severity and prognosis.