MULTİPL PRİMER JİNEKOLOJİK TÜMÖRLER

Objective: To evaluate incidence, clinical and pathological features and survival of patients who had multiple gynecological tumors. Material and methods: 2373 patients treated between 1992 and 2010 with gynecological malignancy were analyzed retrospectively. Multiple gynecological malignancy was observed in 26 (1.09%) patients. While 25 patients had two different malignancy, only one patient had three different primary cancer. Twenty-three patients had synchronous cancer and 3 patients developed metachronous cancer after 7, 22, and 24 years of treatment. 2009 FIGO staging system was used. Overall survival was analyzed by Kaplan-Meier method for endometrium-ovary group. Results: The median age was 51 years (34-79 years). Coexistence of endometrial and ovary cancer was most common (61.5%). Other coexistence of malignancies were; endometrium-cervix (4 patients, 15.3%), cervix-ovary (3 patients, 11.5%), cervix-vagina (2 patients, 7.6%) and endometrium-over-cervix cancer (1 patient, 3.8%). The most common stage and grade were; stage1 and grade1. The most common complaint was abnormal vaginal bleeding. 5 year overall survival was 83% for endometrium-ovary group. Conclusion: Multiple primary gynecological cancer is not common in daily practice. Synchronous endometrial and ovarian cancer is the most common in this population. They have a good prognosis due to detection at a relatively early stage. When we consider the positive impact of early diagnosis for its prognosis, the risk of developing a secondary cancer always should be kept in mind in the presence of a primary malignancy and follow-up of these patients should be done carefully.