Relationship of APACHEII score and B-type natriuretic peptide levels with clinical outcomes in severe pneumonia patients

Objective:To assess the relationship of determine the APACHE Ⅱ score and B-type natriuretic peptide factors with prognosis in patients with severe pneumonia. Method:199 cases with severe pneumonia admitted from Nov 2009 to Mar 2011 were prospectively analyzed,which divided into general treatment and mechanical ventilation group. The vital sign,APACHE Ⅱ score,B-type natriuretic peptide and other biochemical findings were evaluated. And then the relationship between these parameters and clinical outcome was analyzed. Result:63 patients(32%) accepted mechanical ventilation treatment. Compared to the general treatment group,mechnical ventination group demonstrated significant change of respiratory and heart rate.Moreover,APACHE Ⅱ score,B-type natriuretic peptide,blood lactate and Serum creatinine of mechanical ventilation group were significantly increased. APACHE Ⅱ score 8,BNP667 ng/L,Cr 142 μmol/L and Lac 2 mmol/L related to need for mechanical ventilation and 30d mortality in ICU. Conclusion:APACHE Ⅱ score,BNP,Cr and Lac have prognostic value and were reliable markers for predicting both high risk for mechanical ventilation and mortality.