Abstract 553: Inhibition of Microrna-21 Prevents Myocardial Remodelling and Dysfunction in a Pig Model of Ischemia/reperfusion Injury

Deepak Ramanujam,R. Hinkel,Veronika Kazcmarek,Andrea Howe,Katharina Klett,Anne Dueck,Thomas Thum,Karl-Ludwig Laugwitz,Christian Kupatt,Stefan Engelhardt

Abstract 553: Inhibition of Microrna-21 Prevents Myocardial Remodelling and Dysfunction in a Pig Model of Ischemia/reperfusion Injury

2018

Deepak Ramanujam
R. Hinkel
Veronika Kazcmarek
Andrea Howe
Katharina Klett
Anne Dueck
Thomas Thum
Karl-Ludwig Laugwitz
Christian Kupatt
Stefan Engelhardt

Background: Upregulation of microRNA-21 (miR-21) has been associated with myocardial disease and its systemic inhibition was effective in reducing cardiac fibrosis and dysfunction in rodent models....

Keywords:

Diabetes mellitus
Ischemia
Cardiology
Biology
Internal medicine
Reperfusion injury
microRNA
pig model

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