[Effect of different intensity treadmill training on repair of micro-injured Achilles tendon in rats].

目的: 探讨不同强度跑台训练对胶原酶诱导的大鼠跟腱微损伤修复的影响。. Methods: Seventy-two 8-week-old male Sprague Dawley rats (weighing, 200-250 g) were selected. After adaptive treadmill training for 1 week, rats were injected with 30 μL type I collagenase solution (10 mg/mL) into both Achilles tendons to make micro-injured Achilles tendon models. After 1 week of cage feeding, the rats were randomly divided into 3 groups: the control group, the low-intensity group, and the high-intensity group, 24 rats each group. The rats in control group could move freely, and the rats underwent daily treadmill training at the intensity of 13 m/min and 20 min/d in the low-intensity group and at the intensity of 17 m/min and 60 min/d in the high-intensity group. At immediate, 1 week, and 4 weeks after training, bilateral Achilles tendons were collected from 8 rats of each group for gross observation, histological analysis, and mechanical testing. 结果: 训练开始即刻，各组跟腱标本大体观察、组织学观察及半定量评分以及生物力学测试比较，差异均无统计学意义（ P>0.05），提示各组跟腱微损伤模型损伤程度相似，具有可比性。大体观察示，1 周时，各组腱旁结缔组织增生、肌腱组织缺乏光泽；4 周时，低强度组腱旁增生组织较对照组明显减少，而高强度组腱旁结缔组织较多，并且有大量新生血管形成。组织学观察示，1 周时各组间总分比较差异无统计学意义（ P>0.05）；低、高强度组仅新生血管量评分与对照组比较，差异有统计学意义（ P 0.05）。4 周时，低强度组最终应力及抗拉强度较对照组明显升高（ P 0.05）。. 结论: 低强度跑台训练能够促进胶原酶诱导的大鼠跟腱微损伤的修复。.