Efficient InCl3/H2O-Catalyzed One-Pot Stereoselective Synthesis of cis-2-Methyl-4-amido-1,2,3,4-tetrahydroquinoline Derivatives

Abstract Various cis-2-methyl-4-amido-1,2,3,4-tetrahydroquinoline derivatives were synthesized efficiently by reacting aromatic amines and N-vinyl caprolactam or N-vinyl pyrrolidone in the presence of indium trichloride in an aqueous medium in good to excellent yields. These 2,4-disubstituted tetrahydrouinolines showed cis diastereoselectivity.