Mapping of Oxygen Concentration in Biological Samples Using EPR Imaging

Electron paramagnetic resonance (EPR) spectroscopy is widely used for measurement and imaging of oxygen and free radicals in biological systems. EPR oximetry is non-invasive, capable of providing local, reproducible, and repetitive measurements of oxygen concentration or partial pressure of oxygen (pO2) in tissues. Although EPR oximetry is used primarily as a research tool, it has the potential to be useful in the clinic. This review provides a brief overview of the technique and its application to selected biological systems.