Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators

Maria Chatzopoulou,Enrico Emer,Cristina Lecci,Jessica A. Rowley,Anne-Sophie Casagrande,Lee Moir,Sarah E. Squire,Stephen G. Davies,Shawn Harriman,Graham Michael Wynne,Francis Wilson,Kay E. Davies,Angela J. Russell

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators

2020

Maria Chatzopoulou
Enrico Emer
Cristina Lecci
Jessica A. Rowley
Anne-Sophie Casagrande
Lee Moir
Sarah E. Squire
Stephen G. Davies
Shawn Harriman
Graham Michael Wynne
Francis Wilson
Kay E. Davies
Angela J. Russell

Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, ...

Keywords:

Pharmacology
Duchenne muscular dystrophy
Cytotoxicity
Lipophilicity
Utrophin
therapeutic strategy
Chemistry

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