Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats – pharmacokinetic/pharmacodynamic modelling

M. René Bouw,Rujia Xie,Karin Tunblad,Margareta Hammarlund-Udenaes

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats – pharmacokinetic/pharmacodynamic modelling

2001

M. René Bouw
Rujia Xie
Karin Tunblad
Margareta Hammarlund-Udenaes

Blood-brain barrier transport and brain distribution ofmorphine-6-glucuronide in relation to the antinociceptive effect inrats--pharmacokinetic/pharmacodynamic modelling.

Keywords:

Morphine
Endocrinology
Morphine-6-glucuronide
Pharmacodynamics
Microdialysis
Internal medicine
Blood–brain barrier
Nociception
Central nervous system
Pharmacology
Pharmacokinetics
Chemistry

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