LncRNA TP73‐AS1 downregulates miR-139-3p to promote retinoblastoma cell proliferation

Our study aimed to investigate the role of lncRNA TP73-AS1 in retinoblastoma (Rb). In the present study we found that TP73-AS1 was upregulated, while miR-139-3p was downregulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the downregulated miR-139-3p. TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may downregulate miR-139-3p to promote Rb cell proliferation.