EVALUATION OF SAFETY AND EFFICACY OF HYPONIDD, AN AYURVEDIC COMPOUND: A DOUBLE BLIND, PLACEBO CONTROLLED STUDY IN TYPE 2 DIABETIC PATIENTS WITH SECONDARY FAILURE TO ORAL DRUGS

To determine the efficacy of an Ayurvedic preparation, Hyponidd in type 2 diabetic patients with secondary failure to oral hypoglycemic agents, a randomized double blind, single centre, study of 12 weeks duration was carried out. 40 type 2 diabetic patients who satisfied the inclusion criteria were recruited for the study. Out of 40 patients, 32 completed the trial, 16 in the Hyponidd arm and 16 in the placebo arm. There was a non-significant reduction in the fasting and postprandial plasma glucose levels in the group treated with Hyponidd. A significant reduction in the glycosylated haemoglobin levels was noted in the drug group (p<0.05). No adverse events were noted in patients treated with Hyponidd, except for one patient who had elevated liver enzymes.