GPCRs as Targets for Plant-Derived Drugs

The family of GPCRs represents the most important class of pharmaceutical drug targets. In this chapter, we describe such receptors and pathways that are targets for well-known plant-derived drugs and toxins. These include adrenergic receptors, the muscarinic acetylcholine receptor (MAchR), adenosine receptors, cannabinoid receptors, dopamine- and serotonin (5HT) receptors/transporters and opiate receptors. They are targets for compounds such as cannabis, muscarine and atropine, caffeine, cocaine, morphine and hallucinogenic drugs, among others.