Programmable one-pot synthesis of tumor-associated carbohydrate antigens Lewis X dimer and KH-1 epitopes
2011
Abstract The total synthesis of the antigenic Lewis X (Le x ) dimer and KH-1 epitopes by a reactivity-based programmable one-pot synthetic strategy is reported. This approach can minimize the protection–deprotection and purification steps. Using the reactivity-based one-pot synthetic method, the fully protected Lewis X (Le x ) dimer and KH-1 epitopes were furnished in a facile manner, which were globally deprotected to give the Le x dimer and KH-1 epitopes.
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