Synthesis and activity of staurosporine analogs with a lactone functionality
1996
Abstract Staurosporine analogs, whose γ-lactam functionality was converted into γ-lactone, were synthesized. The key step involves remarkably efficient ring-opening and then intramolecular cyclization reactions. In general, those compounds display potent anti-platelet aggregation activity and show higher selectivity against platelet as compared with smooth muscle contraction.
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