One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of α-Nitro Epoxides

Polysubstituted 2-aminothiazoles have been synthesized via a one-pot three-component reaction of α-nitro epoxides, potassium thiocyanate, and primary amines without the need for any additives. This reaction proceeds smoothly in a highly efficient and eco-friendly manner with good to excellent yields. A possible mechanism is also proposed.