VIGNETTE Cetuximab (Erbitux)

SUMMARY: Cetuximab, a recombinant chimeric monoclonal antibody, has been successfully used in the treatment of the head and neck and colorectal cancers. We present a review of its mechanism of action, indications, side effects and economic issues, accompanied by a clinical example from our institution. ABBREVIATIONS: EGFR epidermal growth factor receptor; FDA US Food and Drug Administration; HER human epidermal growth factor receptor; SCC squamous cell carcinoma; SCCHN SCC of the head and neck