Valproic Acid Induces Pro-Survival Transcriptomic Changes in Swine Subjected to Traumatic Injury and Hemorrhagic Shock

BACKGROUNDValproic acid (VPA) is a histone deacetylase inhibitor that improves outcomes in large animal models of trauma. However, its protective mechanism of action is not completely understood. We sought to characterize the genetic changes induced by VPA treatment following traumatic injuries.METH