X‐ray observation of chiral transformations within a metal–peptide pore

Porous metal complexes enable single-crystal X-ray observation of included guests or reaction intermediates by simple soaking of the guests/substrates. Previous studies on such a technique often have difficulties in observation of chiral structures because host frameworks had no chirality. Here, we synthesized a new metal-peptide porous complex via the folding-and-assembly strategy and utilized the chiral pore for trapping chiral guests. Chiral alcohols and ketones were successfully included within the pore. Crystallographic analyses clearly revealed not only their chemical structures but also chiral transformation events within the pore such as fixed conformations or an unstable hemiacetal formation.