Short-term starvation and realimentation helps stave off Edwardsiella tarda infection in red sea bream (Pagrus major)

Abstract Dietary regime modifications have been an integral part of health and healing practices throughout the animal kingdom. Thus, to assess the effects of periodic starvation and refeeding schedule on the physiological and immunological perturbations in Edwardsiella tarda infected red sea bream, we conducted a 20 day experiment using 4 treatment groups, namely, pre-fed placebo (PFP); pre-starved placebo (PSP); pre-fed infected (PFI); and pre-starved infected (PSI), wherein a 5 h E. tarda infection was done on the 11th day. In the present investigation, the pre-starved groups showed significant ( P P PPAR (peroxisome proliferator activated receptors) α transcription in the pre-starved group decreased significantly ( P PPARγ showcased a reverse pattern. The transcription of Hepcidin1 and Transferrin (iron homeostasis related genes), and Cathepsin D and Ubiquitin (programmed cell death related genes) portrayed a time responsive decrease and increase in PSI and PFI groups, respectively. Additionally, in comparison to the PFI group, the PSI fish demonstrated substantially reduced oxidative stress level. Fluorescent Immunohistochemistry showed significant ( P E. tarda infection in red sea bream.