Time Series and Case-Crossover Design-Two Methods to Study the Short-Term Effect of Environment on Pneumothorax.

Spontaneous pneumothorax (SP) does not seem to occur at random. The clinical impression of many physicians is that the patient’s admissions in hospital for pneumothorax are clustered. It supports the hypothesis that the meteorological conditions, or some factors associated with infectious and chronobiological factors, could play an important role in the mechanism of development SP.