Investigation of the Particle Size Distribution of a Model Intravenous Emulsion

The size distribution of a model intravenous (iv) emulsion was investigated with special regard to the lower size classes. The special interest in the lower size classes is related to their possible responsibility for a number of side effects as well as their possible influence on pharmacokinetics of incorporated drugs. The particle size distribution of the unfractionated emulsion observed by photon correlation spectroscopy (PCS) showed no particles with diameters 31 P NMR experiments revealed that -48 mol% of the emulsifier forms particles smaller than —100 nm in diameter. The results from TEM observations and NMR spectroscopy suggest that the majority of particles by number have diameters