Efficacy and Tolerability of a combination product with L-Tryptophan, Griffonia simplicifolia, Vitamin PP and Vitamin B6 in pediatric migraine prophylaxis: an open study

The aim of this study was to evaluate the efficacy and tolerability of combination product with L- tryptophan, Griffonia simplicifolia, Vitamin PP and Vitamin B6 in prophylaxis therapy of pediatric migraine. Fifthy outpatients (32 F, 18 M), mean age 10.7 years (SD 5.8), range 4-18 years, suffering from ICHD-2 migraine without aura were enrolled. The mean duration of disease was 2.9 (SD 1.6) years, range 1-4 years. At baseline the mean frequency of attacks was 7.6/month (SD 3.3), range 4-12; the mean number of drugs intaking for acute attacks was 6.6 tablets/month (SD 2.2). During the six month evaluation period the combination product with L-tryptophan, griffonia simplicifolia, vitamin PP and vitamin B6 was administered (at dose 100 mg, 480 mg, 18 mg and 1 mg/die, respectively). All patients filled a headache-diary card during the evaluation.