Does the treatment of peritonitis affect residual renal function in CAPD

: The aim of the study was a retrospective analysis of potentially negative influence of aminoglycosides on RRF in patients with peritonitis in course of CAPD program. From the group of 47 patients of our center who were treated because of peritonitis in years 1991-2000 we finally selected 11 persons with preserved RRF in whom 16 incidents of peritonitis were revealed. The mean value of RRF in this group was 1.55 (+/- 2.0) ml/min before the treatment and 1.44 (+/- 2.2) ml/mi after the treatment of peritonitis. There was no statistical difference between these values (p = 0.32). It was also revealed that in 5 cases (31%) RRF decreased after the peritonitis treatment while in 7 cases (44%) no change of RRF value was observed and in 4 cases (25%) RRF value was increased after the treatment of peritonitis. The efficacy of treatment with the standard protocol in observed group was 93.75%. On the base of performed analysis no negative influence of peritonitis therapy with aminoglycosides and I-st generation cephalosporines was observed. It was stated that aminoglycosides may still be used in peritonitis therapy under the condition that precise monitoring of RRF will be introduced.