Isolation of 3′-O-Acetylchloramphenicol: A possible intermediate in chloramphenicol biosynthesis
2002
Abstract 3′- O -Acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.
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