Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130

Tumorigenesis has been likened to a form of cellular reversion to the embryonic state. Ma et al. identify a foetal miRNA as an oncogenic activator of the Wnt/β-catenin pathway in colorectal cancer, whose expression is negatively correlated with survival but is positively correlated with response to adjuvant chemotherapy.