Clinical Research Atrial Fibrillation and Congestive Heart Failure: A Cost Analysis of Rhythm-Control vs Rate-Control Strategies

Background: Atrial fibrillation (AF) is common in patients with heart failure. Rhythm- and rate-control strategies are associated with similar efficacy outcomes. We compared the economic impact of the 2 treatment strategies in patients with AF and heart failure from the province of Quebec, Canada. Methods: In a substudy of the Atrial Fibrillation and Congestive Heart Failure trial, health care expenditures of patients from Quebec randomized to rhythm and rate-control treatment strategies were compared from a single-payer perspective using a cost-minimization approach. In-trial resource utilization and unit costs were estimated from Quebec Health Insurance Board databases supplemented by disease-specific costs from the Ontario Case Costing Initiative. Results: In all, 304 patients were included, aged 68 � 9 years; 86% male; ejection fraction, 26% � 6%. Baseline characteristics were similar in rhythm-control (n ¼ 149) and rate-control (n ¼ 155) groups. Arrhythmia-related costs accounted for 45% of total expenditures. Rate-control patients had fewer cardiac procedures (146 vs 238, P < 0.001), driven by fewer cardioversions, and lower costs related to antiarrhythmic drugs (CAD$48 per patient [95% confidence interval {CI}, $21-$96] vs $1319 per patient [95% CI, $1124-$1522]). However, these differences were offset by higher expenditures due to hospitalizations for noncardiovascular diagnoses, implantable cardiac arrhythmia devices, and noncardiovascular drugs in the rate-control group. The total cost per patient was not significantly different RESUME