Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
2020
Although
greener and faster access to fine chemicals and APIs is
highly desirable, there are currently no synthetic methodologies which
undergo reaction completions within a few seconds to minutes in water
under benchtop laboratory conditions. Here, we report a methodology
that allows the instantaneous formation of ligated ultrasmall Pd nanoparticles
in the hydrophobic pockets of benign cellulose derivative (HPMC) for
chemical reactions to proceed very fast in water under mild reaction
conditions. Unprecedented short reaction times were exemplified for
the Buchwald–Hartwig aminations. In addition, very short reaction
times of less than a minute were also demonstrated for the amide couplings,
which is the most utilized reaction type in the pharmaceutical industry.
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