An Efficient Synthesis of a Chiral Carbocyclic 2′‐Deoxyribonucleoside Synthon by Directed Reduction.

Abstract Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ketone 12 with NaBH(OAc)3 gave stereoselectively in high yield the 1,4 diol 10, a key intermediate required in our synthesis of chiral carbocyclic 2′-deoxyribonucleosides.