Investigation of the Lithiation-Trapping of an N-Boc Bispidine-Ketal: Reactivity and Diastereoselectivity
2015
The lithiation-trapping of an N -Boc bispidine-ketal using s -BuLi/TMEDA has been studied. Key findings include an activating effect of the 4-ketal group on the lithiation and complete diastereoselectivity with methylation and Cu-mediated allylation. In contrast, reduced diastereoselectivity was noted for direct allylation and silylation; mechanistic explanations are proposed.
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