Translocations (4p+ 6q−) and (12q− Xp+) in blastic phase of a Ph1-positive chronic myeloid leukemia
1984
This paper reports a 28-year-old woman with Philadelphia chromosome (Ph1)-positive chronic myeloid leukemia (CML) who developed two marrow cell lines during the blastic phase: one with the translocation (12; X) (q 11; p 22) and the other with the translocation (4; 6) (p 16; q 25). The literature on involvement of chromosomes 12 and X in translocations and the appearance of 6 q− aberration in CML is summarized. The relationship between the 6 q− aberration and the blast cells with lymphoid appearance in the plastic phase of CML is discussed.
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