Doxorubicin hydrochloride liposome injection and preparation technology thereof

The invention discloses a doxorubicin hydrochloride liposome injection and a preparation technology thereof. The injection comprises the following components by weight percent: 0.05-0.5% of doxorubicin hydrochloride, 0.025-3% of hydrogenated soybean phosphatidylcholine, 0.001-1.5% of cholesterol, 0.01-1% of PEG-lipid, 0.0025-2.5% of organic acid or ammonium sulfate, 2.8-20% of sugar, 0.1-10% of buffering agent and the balance water for injection. The preparation technology comprises the following steps: 1) freeze-drying lipid phase; 2) hydrating lipid phase; 3) straightening the granules of lipid phase; 4) forming transmembrane gradient inside and outside phospholipid membrane; 5) loading medicine with liposome; and 6) degerming, subpackaging and storing.